What is a ComfortScan System and
how much does it cost?
The ComfortScan System is an advanced digital-imaging system that uses
high-intensity light-emitting diodes (LEDs), gentle external pressure,
a low-noise charged-coupled device (CCD) camera, and proprietary image-processing
algorithms to highlight areas of abnormal vascularization in the breast.
The technology is based on detecting tumor angiogenesis, the growth of
a dense network of tiny blood-filled capillaries that surround a tumor.
Initially, the Company will introduce the ComfortScan System as an adjunct
to x-ray mammography. Pricing is expected to be competitive with analog
mammography systems and ultrasound devices, but it should market at about
one third of the price of the new digital mammography systems.
How does it work?
The ComfortScan System's high-intensity, light-emitting diodes transmit
near-infrared light through the breast, recording one image per second
via a CCD camera for approximately 45 seconds. As the red light encounters
the angiogenic region of the breast, it is absorbed by the different concentrations
of hemoglobin in that area of the breast, in contrast to the normal portions
of the breast. As a result, the ComfortScan System focuses on dynamic
functional imaging (i.e., what is occurring within the tissue in near
real-time) rather than a singular morphological image (i.e., a static
anatomical snapshot showing physical details at a single point in time)
such as those created by mammography.
What is angiogenesis and why is it
Angiogenesis is the growth of new blood vessels in the body, a type of
vascular change. It is an important, natural process that occurs both
in health and disease. Angiogenesis occurs in the healthy body for healing
wounds and for restoring blood flow. The healthy body controls angiogenesis
through a series of "on" and "off" switches, maintaining
a perfect balance between these angiogenesis modulators. However, in a
diseased state, the body loses control over the angiogenesis process.
Angiogenesis-dependent diseases result when new blood vessels either grow
excessively or insufficiently. Excessive angiogenesis occurs in the development
of cancers. New blood vessels feed the cancer, allowing a tumor to grow
up to 16,000 times in size (sometimes in a matter of weeks). At the same
time, cancer cells escape into the circulation via the blood vessels and
lodge into other organs (metastasis).
According to the most recent scientific research from the
Angiogenesis Foundation, angiogenesis is associated with virtually every
type of cancer known. Furthermore, angiogenesis is an underlying indicator
in more than 70 conditions, including cardiac disease, arthritis, AIDS,
ophthalmic and skin diseases, as well as other solid tumors. Angiogenesis
can also impact surgical incisions, trauma-related injuries, and ulcers
that rely on the angiogenic process for healing. The Angiogenesis Foundation
estimates that more than 500 million cases of angiogenesis-based disease
are currently afflicting patients in the western world.
DOBI Medical's technology is built on its ability to identify
angiogenesis non-invasively, thus providing a new tool to potentially
assist physicians in the detection of virtually all cancers, including